Plasma prohepcidin as a negative acute phase reactant after large cardiac surgery with a deep hypothermic circulatory arrest

Title: Plasma prohepcidin as a negative acute phase reactant after large cardiac surgery with a deep hypothermic circulatory arrest

Plasma prohepcidin as a negative acute phase reactant after large cardiac surgery with a deep hypothermic circulatory arrest.

Hepcidin is a key regulator of iron metabolism and a mediator of anemia in inflammation. Recent in vitro studies recognized prohepcidin as a type II acute phase protein regulating via interleukin-6. The aim of the present study was to investigate the time course of plasma prohepcidin after a large cardiac surgery in relation to IL-6 and other inflammatory parameters. Patients with chronic throm...

Deep hypothermic circulatory arrest.

Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes, necessitating the adjunctive use of antegr...

Vancomycin plasma concentrations in cardiac surgery with the use of profound hypothermic circulatory arrest.

OBJECTIVE This study was undertaken to compare the effect of deep hypothermic circulatory arrest, compared with moderate hypothermia, on the plasma concentrations and pharmacokinetic profile of vancomycin, administered as prophylaxis, in patients undergoing cardiac surgery with cardiopulmonary bypass. METHODS Two groups of adult cardiac surgery patients were prospectively studied. One group c...

Perioperative management of deep hypothermic circulatory arrest.

m d t r e t n a a h c n i l r t 1 t d u t 2 g g l t HE GOAL OF this article is to provide a review of deep hypothermic circulatory arrest (DHCA), covering major isues including pathophysiology of ischemic injury, organ protecion (both pharmacologic and nonpharmacologic), temperature ontrol, and perfusion methods. The purpose of this review is to erve as a resource for board review or as introdu...